P.V. Ramana Murthy was born and raised in a religious Hindu home. One of his relatives introduced him to Jesus Christ during a difficult time. He then sought help from a pastor to learn more about Jesus Christ and found comfort in his problems. After realising how radically his life had changed, he accepted Jesus Christ as his personal Saviour. He continued to serve the Lord in various ministries in a local church as his faith grew with time.
He is an employee in the mechanical division of the Visakhapatnam Port Trust. He married Venkata Lakshmi, and they have two children, Hadassah and Sunil Kumar, and one granddaughter.